Pharmaceutical Demulsifier （Penicillin Specific）

Introduction to penicillin

Since 1928, British bacteriologist Fleming first discovered the world’s first antibiotic – penicillin, has been a hundred years of history. Penicillin (Penicillin, or transliteration of penicillin), also known as penicillin G, peillin G, is a class of antibiotics containing penicillane, which can destroy the cell wall of bacteria and play a bactericidal role in the breeding period of bacterial cells. It is extracted from penicillium. Penicillin is currently the largest production, the most widely used antibiotic, has the advantages of strong antibacterial action, high efficacy, low toxicity, is the first choice for the treatment of sensitive bacterial infections, among which penicillin potassium salt, cephalosporin has the best effect, the most widely used.

The production process of penicillin G can be divided into two steps: strain fermentation and extraction and refining. ① Strain fermentation: the penicillium is inoculated on the solid medium to culture penicillium spores. Then, the seed culture medium was inoculated into the sterilized culture medium containing phenylacetic acid precursors in the fermenter, sterile air was injected, stirred, and culture fermented to obtain penicillin fermentation liquid. ② Extraction and refining: the penicillin fermentation liquid is cooled and filtered. In the filtrate extractor, butyl acetate was used for multistage countercurrent extraction to obtain butyl ester extract. The butyl ester extract was decolorized by activated carbon, then added to the salt agent and azeotropic distillation to obtain potassium penicillin G. Penicillin G sodium salt is prepared from penicillin G potassium salt by ion exchange resin (sodium type).

Introduction of  Pharmaceutical Demulsifier

An important process in the production of penicillin is the extraction of penicillin from penicillin fermentation broth with organic solvents such as butyl acetate. Because the fermentation liquid contains complex substances such as protein, sugar and mycelium, the interface between the organic phase and the water phase is unclear during extraction, and it is an emulsifying zone of certain strength, which has a great influence on the yield of the finished product. To this end, demulsifier must be used to demulsify, eliminate emulsification phenomenon, and achieve rapid and effective two-phase separation. However, different demulsifiers have different demulsification ability on organic phase, and the performance of demulsifier directly affects the effect of two-phase separation

This product is water soluble, acid medical demulsifier, specially used in penicillin manufacturing. This product strictly follows the professional standards of pharmaceutical chemical products, adopts a mixed surfactant system, and makes use of the synergy and good compatibility between surfactants. Its main advantages are:

1, this product can eliminate the interference of the electric coupling layer, quickly close to the emulsifying interface, so that the two-phase interface is easier to separate, thus greatly improving the demulsification ability of the fermentation liquid. This demulsifier has excellent demulsification separation effect.

2, this product has no bad odor, good impurity removal rate, no residue in the ester phase of the extraction layer, which is conducive to improving the quality of penicillin products.

3, the amount of this product is small, can significantly improve the penicillin yield, the yield can be stable at more than 94%, saving penicillin production cost.

4, this product has excellent chemical stability, non-toxic, pollution-free, easy to use, strong adaptability.

To sum up, this demulsifier is an essential and excellent auxiliary agent in the production of penicillin.

Demulsification effect diagram: